SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model모유는 장 모델에서 SARS-CoV-2를 포함한 일부 외피 바이러스 감염을 억제합니다Article Published on 2022-08-042022-09-11 Journal: Life Science Alliance [Category] SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibodies antiviral activity ATP1A1 block blocked change Complete inhibition coronavirus Culture Defense demonstrated down-regulation endocytic evaluated fetal Human human milk Infant Infants Infection infections inhibit inhibition intestinal intestinal cell Middle East Middle East respiratory syndrome Coronavirus milk monolayer no effect Protective respiratory respiratory syncytial virus respiratory syndrome coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike-specific severe acute respiratory syndrome Coronavirus specific antibodies subsequent suggested Transcriptome transcriptome analysis transcriptomic treated Treatment virus virus viruses [DOI] 10.26508/lsa.202201432 PMC 바로가기 [Article Type] Article
Differences in endosomal Rab gene expression between positive and negative COVID-19 patientsCOVID-19 양성 및 음성 환자 간의 엔도솜 Rab 유전자 발현의 차이Article Published on 2022-07-152022-09-11 Journal: BMC Research Notes [Category] 유전자 메커니즘, [키워드] ACE2 analysed control group coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patient difference endocytic Endocytic pathway epithelial etiologic agent expression Gene Expression groups host cell Infection internalization Mann Whitney U Test mRNA patients performed positive Proteins Rab Rab11b Rab5 Rab7 RNA RT-PCR SARS CoV SARS CoV-2 SARS CoV-2 infection significant difference significant differences significantly significantly increased Statistical tests Test viral entry viral entry. virus [DOI] 10.1186/s13104-022-06144-7 PMC 바로가기 [Article Type] Article
Sars-Cov-2 Spike Protein-Induced Damage of hiPSC-Derived CardiomyocytesSars-Cov-2 스파이크 단백질에 의한 hiPSC 유래 심근세포 손상Article Published on 2022-07-012022-09-12 Journal: Advanced Biology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 alteration Ang II angiotensin-converting enzyme 2 Cardiomyocytes chromatin cleavage complex connexin Culture damage downregulated Effect endocytic expression fluctuation functional hiPSC host cells incubated investigated margination molecular pluripotent stem cell Protein Proteins receptor SARS-CoV-2 spike Spike protein spike protein. Spike proteins Structure subunit the spike protein undergo virus while [DOI] 10.1002/adbi.202101327 PMC 바로가기 [Article Type] Article
Many Keys Unlock the Doors for Virus Entry많은 키가 바이러스 진입을 위한 문을 엽니다Comment Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] activities cathepsin characterized complexes component components coronavirus coronavirus Coronaviruses door endocytic endosome Endosomes filovirus filoviruses Genome host cells inactivation infect Influenza Influenza virus mBio membrane membrane fusion promote protease Protein protein complex protein complexes Proteins raise respond SARS-CoV-2 variant Trigger vacuolar vesicles virus virus entry Virus entry. VPS29 zoonotic [DOI] 10.1128/mbio.00445-22 PMC 바로가기 [Article Type] Comment
The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell—Cell Junctions of Epithelial CellsArticle Published on 2022-02-112022-10-31 Journal: Cells [Category] Coronavirus, [키워드] ACE2 ACE2 mRNA ACE2 protein ADAM17 Apical apical surface association Bacterial Caco-2 CD9 Cell—Cell junctions co-immunoprecipitation coronavirus cultured cell endocytic epithelial epithelial cell epithelial cells epithelium experiments expressed expression identify immunofluorescence microscopy intestinal junction kidney Localized mammary observation promote Protein protein complex Proteins receptor ACE2 target tight junction tissue tissues toxins transmembrane transmembrane protein upregulated virus [DOI] 10.3390/cells11040627 PMC 바로가기 [Article Type] Article
SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry423 Published on 2022-01-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome analyses binding C terminal Cell cell entry cell surface pathway complex coronavirus cytosolic demonstrated domain endocytic Endocytic pathway enzyme functional fusing homeostasis host cell inhibiting Interaction Invasion membrane fusion motif physiological conditions plasma membrane Prevent Protein RBD recent regulate Regulation resulting retromer SARS coronaviruses SARS-CoV-2 SARS-COV-2 infection Significance SNX27 suppresse surface receptor therapeutic target type I viral entry virus was used [DOI] 10.1073/pnas.2117576119 PMC 바로가기 [Article Type] 423
TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionTMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다Research Article Published on 2021-11-222022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘, [키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus virus entry virus infection virus infections viruses [DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article
SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathwayOriginal Article Published on 2021-10-082022-10-30 Journal: MedComm [Category] COVID-19, [키워드] abrogation ACE2 addition approach bind binding Critical decrease defined Degradation Depletion docking domain endocytic endocytic trafficking endosomal trafficking endosome expression facilitate Factor Genetic highlight Host host cells host–pathogen interaction impair Infection interact lysosomal mechanism membrane motif pathway promote Protein Proteins receptor ACE2 required RNA virus S protein SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 SNX27 Spike protein Stage Transport virion virus infection [DOI] 10.1002/mco2.92 PMC 바로가기 [Article Type] Original Article
Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors산성화 억제제에 의한 이중 억제 메커니즘을 사용하여 SARS-CoV-2 진입 및 감염을 표적으로 하는 전략Research Article Published on 2021-07-122022-09-10 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 Acidic Affect Alter Antiviral effect applicability assist attenuate Cell cells cellular mechanism cellular mechanisms Chloroquine clathrin Clathrin-mediated endocytosis Clinical management drug ectopic expression endocytic Endocytic pathway endosomal Endosomal acidification endosomal pH expressing expression FDA-approved drug FDA-approved drugs Host host cell host cells human cells Infection inhibit inhibitor mechanism neutralize niclosamide observation pathway Prevent RBD Receptor binding domain reduce SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein screened Spike protein Strategy subset Therapeutic strategies tracing undetectable Vero Cell Vero cells Viral viral entry viral infections virus virus viruses [DOI] 10.1371/journal.ppat.1009706 PMC 바로가기 [Article Type] Research Article